Sarcoma research papers

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Interdisciplinary therapy of extremity soft tissue sarcomas: current evidence on systemic treatments and the role of reconstructive surgery. reports: Soft tissue sarcomas are rare and heterogenous tumors, that often pose diagnostic and therapeutic challenges. Guideline-compliant therapy includes surgical resection with negative margins, supplementary radiotherapy and, if necessary, accompanied by systemic therapy. Diagnostic and therapeutic approaches should be discussed and planned in an interdisciplinary oncological conference.

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Evaluating the Cost of Genomic Testing for Biomarker-Driven Therapies in Oncology. reports: Genomic profiling is used in the diagnosis, monitoring, and treatment of malignancies. Comprehensive genomic profiling (CGP) is a next-generation sequencing (NGS) approach that can test multiple genes simultaneously, potentially saving time, money, and sample material. Costs associated with genomic profiling could be a prohibitive barrier to the widespread implementation of genomic testing in routine clinical practice.

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High-Dose Continuous Infusion Ifosfamide as Effective Palliation in a Patient With Relapsed Ewing Sarcoma With Bone Marrow Infiltration and Severe Thrombocytopenia: A Case Report. reports: Ewing sarcoma is a rare primary mesenchymal tumor of the bone that requires an intensive multimodal therapeutic approach. Multidrug chemotherapy regimens are also the backbone for relapsing/recurring Ewing sarcoma treatment, yet when the disease relapses as bone marrow infiltration, combination chemotherapy might be difficult to administer and prognosis is poor. This report describes the case of a 22-year-old patient with Ewing sarcoma who developed severe pancytopenia due to bone marrow infiltration, and who was treated with high-dose continuous infusion ifosfamide, obtaining both clinical, radiological, and hematological response lasting for about 7 months.

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Primary synovial sarcoma of the pericardium diagnosed after multiple biopsies following recurrent episodes of haemorrhagic pericardial effusion following infection: a case report. reports: Primary malignant pericardial tumours are extremely rare, and synovial sarcoma arising from the pericardium is an exceptionally uncommon entity with poor survival. Diagnosis is often delayed because initial pericardial biopsies can be non-diagnostic, and distinguishing between inflammatory disease and malignancy may be challenging. An 11-year-old boy developed recurrent fever and chest pain 15 days after Coronavirus disease 2019 infection.

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Nodular Fasciitis of the Carpus Mimicking Metastasis in a Multi-cancer Survivor. reports: Nodular fasciitis is a benign reactive fibroproliferative lesion that is exceedingly rare within the wrist and hand, particularly when involving bone. Its rapid growth and clinical presentation can often mimic sarcomas or metastatic disease, creating a significant diagnostic challenge. We report the case of a 59-year-old male patient with a history of multiple malignancies who presented with a rapidly enlarging dorsal wrist mass.

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Discovering Signature Disease Trajectories in Pancreatic Cancer and Soft-tissue Sarcoma from Longitudinal Patient Records reports: Understanding the disease trajectories of specific diseases can provide important clinical insights. In this paper, we aimed to discover signature disease trajectories of 3 rare cancer types: pancreatic cancer, soft tissue sarcoma (STS) of the trunk and extremity (STS-TE), and STS of the abdomen and retroperitoneum (STS-AR), leveraging IQVIA Oncology Electronic Medical Record. We identified significant diagnosis pairs in patients with these cancers through matched cohort sampling, statistical computation, right-tailed binomial hypothesis test, and visualized trajectories up to 3 progressions. This is a preprint and not peer reviewed.

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Expression patterns of fibroblast activation protein and extra-domain B fibronectin in canine malignant tumors. reports: Fibroblast activation protein (FAP) is involved in the extracellular matrix (ECM) remodeling and wound healing. Absent in most adult tissues, it is overexpressed by neoplastic cells and/or cancer-associated fibroblasts (CAFs) in several human malignancies. The extra Domain-B of fibronectin (EDB+FN) is a splice variant of fibronectin involved in angiogenesis and tissue remodeling, overexpressed by CAFs and cancer-associated vessels (CAVs) in many aggressive human tumors.

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