Topics
Treatment
Modality
Immunotherapy, Targeted therapy, Cell therapy, Imaging
Study type
Not listed
Abstract
Fibroblast activation protein (FAP) is involved in the extracellular matrix (ECM) remodeling and wound healing. Absent in most adult tissues, it is overexpressed by neoplastic cells and/or cancer-associated fibroblasts (CAFs) in several human malignancies. The extra Domain-B of fibronectin (EDB+FN) is a splice variant…
Authors
Silvia Dell'Aere, Elisa Maria Gariboldi, Alessandra Ubiali, Roberta Ferrari +12
AI-generated summary
Expression patterns of fibroblast activation protein and extra-domain B fibronectin in canine malignant tumors. reports: Fibroblast activation protein (FAP) is involved in the extracellular matrix (ECM) remodeling and wound healing. Absent in most adult tissues, it is overexpressed by neoplastic cells and/or cancer-associated fibroblasts (CAFs) in several human malignancies. The extra Domain-B of fibronectin (EDB+FN) is a splice variant of fibronectin involved in angiogenesis and tissue remodeling, overexpressed by CAFs and cancer-associated vessels (CAVs) in many aggressive human tumors.
This summary may be inaccurate. Verify with the primary paper.
Primary source: PubMed.