Non-melanoma skin cancers research papers

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Evolving paradigms in the management of basal cell carcinoma. reports: Basal cell carcinoma (BCC) remains the most common malignancy worldwide. While the majority of tumors are curable with surgery, a subset of locally advanced or metastatic cases requires systemic therapy. Over the last few years, a surge of translational and clinical advances has reshaped management, from Hedgehog pathway inhibition to immune checkpoint blockade and perioperative integration.

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Skin cancer screening in solid organ transplant recipients: development of the SUNTRAC tool. reports: To summarize the development, validation, and current clinical use of the Skin and Ultraviolet Neoplasia Risk Assessment Calculator (SUNTRAC) tool. We also discuss key gaps, including the need for greater personalization, incorporation of additional risk factors, and clearer clinical protocols to support its integration into routine care. Skin cancer remains the most frequent malignancy in solid organ transplant recipients (SOTRs), driven by long-term immunosuppression and other patient-specific risk factors.

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Immune Checkpoint Inhibitors for the Treatment of Periorbital Non-Melanoma Skin Cancers. reports: Non-melanoma skin cancers (NMSCs) of the periocular region present significant clinical challenges, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most prevalent. The purpose of this study is to report on the outcomes of anti-programmed death (PD-1)/PD-L1 immunotherapy in patients with locally advanced periorbital NMSCs. We conducted a retrospective study of the patients treated for locally advanced periocular BCC and cutaneous SCC using anti-PD-1/PD-L1 immunotherapy from January 2016 to January 2023.

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Clinical and Pathological Characteristics of Skin Cancer Patients at Southern Medical University, Guangzhou, China. reports: The incidence of skin cancer is increasing in China, yet large-scale clinical and pathological data from China remain scarce. A retrospective analysis was conducted of 648 histopathologically confirmed skin cancer cases diagnosed at the Dermatology Hospital, Southern Medical University from January 2020 to July 2023. Patient demographics, tumour distribution, histological subtypes, and treatment approaches were evaluated.

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Teledermatology and face-to-face pathways for basal cell carcinoma diagnosis in a southern European cohort: a comparative histopathologic analysis. reports: Teledermatology has expanded markedly in the post-pandemic era; however, its impact on the histopathologic presentation of basal cell carcinoma (BCC) remains insufficiently characterized. Tumor depth and histologic subtype are key prognostic factors and may differ according to diagnostic pathway. We conducted a retrospective observational study at a tertiary referral hospital in southern Europe, including all histologically confirmed BCCs diagnosed in 2019 through face-to-face dermatology and in 2022 through teledermatology.

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