Kidney (Renal) cancer research papers

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Health and productivity benefits of anti-PD-(L)1 agents for early-stage cancer treatment in Hungary. reports: Anti-PD-(L)1 agents, inhibitors of programmed cell death protein 1 (PD-1) or its ligand (PD-L1), are established therapies that improve cancer management as well as the disease and societal burden of specific metastatic and early-stage cancers. The aim of the study was to determine the impact of adopting anti-PD-(L)1 agents for the treatment of all eligible patients with early-stage cancers versus reserving anti-PD-(L)1 agents for patients with metastatic disease alone in Hungary. This study evaluated two scenarios, one where anti-PD-(L)1 agents were used to treat all eligible early-stage disease case s (ESD scenario) of melanoma (stage IIB-C and III), renal cell carcinoma (RCC), and triple-negative breast cancer (TNBC) versus a reference scenario where anti-PD-(L)1 agents were only used to treat metastatic disease cases in Hungary (2024-2033).

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A rare renal neoplasm: Case report of mucinous tubular and spindle cell carcinoma. reports: Mucinous tubular and spindle cell renal cell carcinoma (MTSRCC) is a rare subtype of renal cell carcinoma with distinctive histological features and generally favorable prognosis. We report the case of a 52-year-old woman who presented with right lumbar pain. CT and MRI revealed a well-defined solid renal mass with mild, homogeneous enhancement.

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Prevalence of KDM6A deficiency in human cancer: A tissue microarray study on 18,570 cancers from 153 different tumor types. reports: KDM6A is a critical part of the COMPASS-like complex. KDM6A deficiency may result in EZH2 dependency. KDM6A deficiency was analyzed by immunohistochemistry on a tissue microarray containing 14,814 samples from 153 different tumor entities and 76 different normal tissue types.

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Clear Cell Renal Cell Carcinoma Involving Intrarenal Adrenal Tissue: A Rare Case With Staging Implications. reports: The presence of intrarenal adrenal tissue is a rare finding that complicates the staging of renal cell carcinoma, particularly in distinguishing between adrenal-renal fusion and ectopic adrenal remnants. These conditions, though rare, have unique implications for tumor staging and management. We present a case of a 47-year-old woman with a lesion of the right kidney incidentally discovered during imaging for ulcerative colitis.

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Platelet-to-lymphocyte ratio for prognostication in immune checkpoint inhibitor-treated cancer patients: a meta-analysis of 13027 patients highlighting nivolumab-responsive renal cell carcinoma. reports: To assess platelet-to-lymphocyte ratio (PLR) prognostic utility for overall (OS) and progression-free survival (PFS) in immune checkpoint inhibitor-treated cancer patients, and examine impacts of geography, cancer type, cutoff, ICI class, treatment line and stage. A systematic literature search identified studies investigating PLR and prognosis in ICI treated patients. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using random-effects models.

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Tumor-associated neutrophils in renal cell carcinoma. reports: Renal cell carcinoma (RCC) is an immunogenic tumor in which tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs) represent a functionally important component of the tumor microenvironment. Recent studies have revealed pronounced phenotypic heterogeneity of RCC-infiltrating neutrophils, including interferon-responsive, immunosuppressive PMN-MDSC-like, pro-angiogenic, and NET-forming subsets that cannot be adequately described by the classical N1/N2 model. Their polarization is shaped by ELR + CXC chemokines (CXCL1, CXCL8), cytokine signals, systemic inflammation, hypoxia driven by VHL/HIF pathways, and tumor-intrinsic oncogenic alterations such as PTEN loss, ERβ- and c-Myc-dependent programs, as well as epigenetic remodeling.

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Crosstalk between Proline Hydroxylation and Histidine Methylation Regulates Actin-Dependent Cell Mobility Control reports: Actin filaments generate intrinsic forces that are essential for cell motility. This process is tightly regulated by various posttranslational modifications (PTMs), including acetylation, arginylation, and oxidation. However, the role of actin hydroxylation in regulating its dynamics remains poorly understood. This is a preprint and not peer reviewed.

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Unlocking economic gains: the impact of image-guided brachytherapy on cervical cancer treatment in Thailand. reports: This study aims to bridge the existing gap in knowledge by assessing the financial impact of image-guided brachytherapy (IGBT) in the management of cervical cancer in Thailand. A web-based questionnaire was developed in 2019 to collect data from 14 radiotherapy centers across all regions of Thailand. The survey gathered information on the use of brachytherapy for cervical cancer treatment, encompassing both conventional brachytherapy (point-based prescription) and IGBT (volume-based prescription).

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