Glioma research papers

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Heptazine Based Photo-Programmable Azobenzene-Amino Acid Nanotubes for Augmented Drug Delivery and Chemo-Photodynamic Therapy in Glioma. reports: Heptazine or tri-s-triazine, is one of the oldest known nitrogen-containing heterocycles that kindled a new arena in biomedical research in the recent past due to their rich fascinating properties. Here, we report design and development of self-assembled nano biomaterials consisting of heptazine-derived π-conjugated azobenzene for photo-activated glioma therapy. The model anti-cancer drug, Docetaxel is co-assembled with heptazine-derived π-conjugated Azobenzene and Fmoc-Isoleucine-OH to form stable Tubular nanostructures (Dtx@AI-Ts).

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Tumor-associated astrocytes augment cholesterol synthesis to support glioblastoma growth through alternatively spliced Quaking (QKI) isoforms. reports: Glioblastoma (GBM) is a highly aggressive brain tumor with limited treatment options. Tumor-associated astrocytes (TAAs) are crucial components of the GBM microenvironment, yet the contribution of alternative splicing (AS) in TAAs to tumor progression remains unclear. Transcriptomic and molecular analyses of GBM-associated astrocytes revealed a GBM-induced isoform switch in the RNA-binding protein Quaking (QKI) from the QKI-6 isoform to QKI-5 isoform.

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Transfer Learning Strategies for Pathological Foundation Models: A Systematic Evaluation in Brain Tumor Classification. reports: Deploying pathology AI at individual hospitals faces challenges including limited cases and adapting pretrained models to local data. Brain tumor classification, with diverse diagnostic categories but few cases per institution, represents this challenge. Foundation models may offer a solution, but optimal transfer learning strategies remain unclear.

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A Decade of Oncolytic Virotherapy in Pediatric Cancers: A Systematic Review of Safety, Immune Awakening, and Emerging Efficacy. reports: Oncolytic virotherapy employs genetically modified viruses to selectively lyse tumor cells while activating antitumor immune responses. In pediatric oncology, where outcomes for high-grade gliomas and refractory solid tumors remain poor, oncolytic viruses represent a promising therapeutic strategy. A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, including searches of PubMed, Embase, Scopus, Web of Science, and ClinicalTrials.gov for studies published between 2015 and 2025 that evaluated oncolytic virotherapy in patients aged 18 years or younger.

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Sulfasalazine-Induced Urinary Normetanephrine Elevation Mimicking Recurrent Phaeochromocytoma-A Case Report. reports: Phaeochromocytomas and paragangliomas (PPGLs) are catecholamine-secreting neuroendocrine tumours (NETs) of the adrenal medulla and autonomic nervous system. Early recognition and management is critical given their potential morbidity and mortality. For this reason, stand-alone screening investigations rely on a low diagnostic threshold, achieving high sensitivity at the relative cost of specificity.

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Differential migration mechanics and immune responses of glioblastoma subtypes reports: Glioblastoma remains a deadly cancer driven in part by invasion of tumor cells into the brain. Transcriptomic analyses have identified distinct molecular subtypes, but mechanistic differences that account for clinical differences are not clear. Here, we show that, as predicted by the motor-clutch model of cell migration, mesenchymal glioma cells are more spread, generate larger traction forces, and migrate faster in brain tissue compared to proneural cells. This is a preprint and not peer reviewed.

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Gene Set Analysis for time-to-event outcome with the Generalized Berk-Jones statistic reports: Gene set analysis evaluates the collective impact of groups of genes on an outcome of interest, such as disease occurrence. By incorporating biological knowledge through predefined gene sets, this approach enhances the interpretability of results and improves statistical power compared to gene-wise analyses. In the context of time-to-event data, existing methods are limited and fail to account for potentially strong correlations within gene sets. This is a preprint and not peer reviewed.

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BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma reports: Resistance to BRAF plus MEK inhibition (BRAFi+MEKi) in BRAFV600E-mutant gliomas drives rebound, progression, and high mortality, yet it remains poorly understood. This study addresses the urgent need to develop treatments for BRAFi+MEKi-resistant glioma in novel mouse models and patient-derived materials. BRAFi+MEKi reveals glioma plasticity by heightening cell state transitions along glial differentiation trajectories, giving rise to astrocyte- and immunomodulatory oligodendrocyte (OL)-like states. This is a preprint and not peer reviewed.

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A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma reports: A greater understanding of the biology of nevi will provide insights into the etiology of melanoma. Our large-scale meta-analysis of 14 nevus genome-wide association study (GWAS) included 85,967 individuals of European ancestry. We identified 29 nevus-associated loci (p < 5x10-8), of which 24 were not previously reported in a GWAS conducted for nevus count alone. This is a preprint and not peer reviewed.

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DUNE: a versatile neuroimaging encoder captures brain complexity across three major diseases: cancer, dementia and schizophrenia reports: Magnetic resonance images (MRI) of the brain exhibit high dimensionality that pose significant challenges for computational analysis. While models proposed for brain MRIs analyses yield encouraging results, the high complexity of neuroimaging data hinders generalizability and clinical application. We introduce DUNE, a neuroimaging-oriented encoder designed to extract deep-features from multisequence brain MRIs, thereby enabling their processing by basic machine learning algorithms. This is a preprint and not peer reviewed.

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