Ewing sarcoma research papers

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High-Dose Continuous Infusion Ifosfamide as Effective Palliation in a Patient With Relapsed Ewing Sarcoma With Bone Marrow Infiltration and Severe Thrombocytopenia: A Case Report. reports: Ewing sarcoma is a rare primary mesenchymal tumor of the bone that requires an intensive multimodal therapeutic approach. Multidrug chemotherapy regimens are also the backbone for relapsing/recurring Ewing sarcoma treatment, yet when the disease relapses as bone marrow infiltration, combination chemotherapy might be difficult to administer and prognosis is poor. This report describes the case of a 22-year-old patient with Ewing sarcoma who developed severe pancytopenia due to bone marrow infiltration, and who was treated with high-dose continuous infusion ifosfamide, obtaining both clinical, radiological, and hematological response lasting for about 7 months.

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Assessment of combined efficacy of Drakshaguduchyadi gargling and Khadiradi Vati lozenges in curative-intent radiotherapy-induced xerostomia in head-and-neck cancer. reports: Xerostomia is a common adverse effect of radiotherapy for head-and-neck cancers, leading to significant impairment of oral health and overall quality of life. Evidence-based guidelines for managing radiation-induced xerostomia remain limited, and the majority of available options provide only temporary symptomatic relief. In Ayurveda, this condition is described under mukharoga (oral diseases).

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Clinical and laboratory characteristics of patients infected with Shewanella species at a tertiary hospital in Hefei City, China: a retrospective analysis. reports: Shewanella species ( Shewanella spp.) were emerging and rare pathogens. Very few studies had focused on Shewanella spp. infection due to its low incidence.

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Ddx3x regulates B-cell development and immunoglobulin rearrangement in mice reports: The X chromosome gene, DDX3X, is an ATP-dependent RNA helicase with roles in transcription, splicing, nuclear export, and translation. Loss of function mutations in DDX3X are linked to a variety of neoplasms, including B-cell lymphoma. We find that conditional homozygous deletion (Mb1-Cre) of Ddx3x in developing mouse B cells in female mice results in a complete absence of mature peripheral B cells associated with an absolute block at the pro-B cell stage of development in the bone marrow. This is a preprint and not peer reviewed.

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Changes in oral risk habits and influencing factors among participants in an oral cancer screening program reports: This study examines changes in oral risk habits and identifies factors influencing these changes among participants in a population-based oral cancer screening program to support effective public health interventions. The study included 2,569,920 individuals aged 30 and older who participated in Taiwans Oral Cancer Screening Program at least twice between 2010 and 2021. Changes in cigarette smoking and betel quid chewing were assessed between the first and last screenings and categorized as improved, unchanged, or worsened. This is a preprint and not peer reviewed.

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