Endometrial (Uterine) cancer research papers

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Oxidative stress-mediated responses in endometrial cancer cells: contrasting effects of doxorubicin and menadione. reports: Oxidative stress plays a crucial role in the development and treatment response of endometrial cancer, yet the antioxidant defense mechanisms in different tumor subtypes remain unclear. We investigated the cellular response to oxidative (menadione) and genotoxic (doxorubicin) stress in two TP53-mutated endometrial cancer cell lines, AN3CA and KLE. Cell viability, reactive oxygen species (ROS) levels, and the expression of antioxidant-related genes (SESN2, SESN3, SOD1) were assessed using qPCR and In-Cell Western assays.

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The dysregulation of the immune microenvironment during endometrial intraepithelial neoplasia serves as a marker of endometrial carcinogenesis. reports: The development of endometrial cancer is a gradual malignant transformation process driven by multiple factors, and the immune microenvironment is closely related to clinical outcomes and immunotherapy responses. Under physiological conditions, the immune microenvironment of the normal endometrium undergoes periodic reshaping under the regulation of estrogen and progesterone, maintaining the balance between immune defense and reproductive capacity. However, continuous exposure to risk factors, such as non-antagonistic estrogen, may trigger endometrial intraepithelial neoplasia.

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Integrative Multi-omics of Gynecological Tumors Identifies Novel Singular Biomarkers of Disease Progression reports: Gynecological cancers represent a cluster of largely preventable and treatable diseases afflicting women, but with persistent substantial global burden of disease complicated by extant social factors especially in developing countries. Cervical, ovarian and endometrial cancers comprise the major gynecological cancers that might benefit from early-stage diagnosis and personalized treatment strategies. In this work, we performed integrative multi-omics analysis of public-domain omics datasets from The Cancer Genome Atlas consortium and coupled it with custom protocols to identify consensus candidate biomarkers of each of the major gynecological cancers. This is a preprint and not peer reviewed.

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A Non-Invasive Ultrasound-Based Model for Assessing Endometrial Cancer Risk in Postmenopausal Bleeding reports: AimsThis study evaluates the risk of endometrial carcinoma in postmenopausal women presenting with bleeding using an ultrasound-based risk scoring system. It aims to integrate imaging parameters and clinical variables for improved differentiation between benign and malignant endometrial conditions. MethodsA prospective analysis was conducted on postmenopausal women presenting with bleeding per vagina. This is a preprint and not peer reviewed.

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Risk Stratification for Endometrial Cancer Reveals Independent Contributions of Polygenic Risk and Body Mass Index reports: BackgroundObesity is a major risk factor for endometrial cancer, but it is unknown whether it impacts the association between genetic risk and endometrial cancer. We incorporated polygenic risk score and epidemiological risk factors in the prediction of and investigated associations of BMI and polygenic risk score with endometrial cancer risk MethodsWe generated polygenic risk score for endometrial cancer in 129,829 unrelated female participants of European ancestry (including 956 incident cases with endometrial cancer) in the UK Biobank and predicted endometrial cancer using endometrial cancer polygenic risk score and established epidemiological risk factors, including BMI. We evaluated the performance of endometrial cancer prediction models by odds ratios and area under the receiver operating characteristic curves (AUCs) to using logistic regression. This is a preprint and not peer reviewed.

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Cancer risks for MSH6 pathogenic variant carriers reports: IntroductionLynch syndrome (LS) is a hereditary cancer syndrome caused by (likely) pathogenic variants (LP/P) in DNA mismatch repair genes, including MSH6. It is associated with elevated lifetime risks for colorectal cancer (CRC), endometrial cancer (EC), and other malignancies. However, cancer risks specific to MSH6-associated LS, particularly for non-colorectal cancers, remain poorly defined. This is a preprint and not peer reviewed.

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