Cervical cancer research papers

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Direct detection of rare circulating tumor cells in peripheral blood mononuclear cells by scRNA seq: Spike-in strategy based feasibility study. reports: Circulating tumor cells (CTC) provide a minimally invasive window into metastatic disease but are difficult to detect and estimate due to their rarity and heterogeneity. Conventional enrichment-based approaches introduce selection bias and fail to capture diverse CTC populations. Single-cell RNA sequencing (scRNA seq) enables unbiased transcriptomic profiling of diverse cell types and rare population within complex samples like blood.

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Cultural and religious influences on parental knowledge of HPV infection and female vaccination in Egypt: a national cross-sectional study. reports: Human Papilloma Virus (HPV) is one of the most prevalent sexually transmitted infections worldwide, significantly contributing to cervical and other cancers. In Egypt, where cultural and religious norms shape health perceptions, HPV prevention, especially vaccination, remains a critical public health issue. This study investigates parental knowledge and attitudes towards HPV infection and vaccination in Egypt, focusing on the influence of cultural and religious beliefs.

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[Geomapping of 10-year coverage rate of cervical cancer screening in Sweden - a basis for targeting population-level interventions to improve screening]. reports: A high coverage rate of cervical cancer screening is necessary to prevent cervical cancer. Women who have not been tested in the last 10 years are considered as long-term non-attenders from the screening program. A recent report from the Regional Cancer Centers in Sweden addressed geographic disparities in the 10-year coverage rate among 33-62-year-old women residing in Sweden in 2023, and compared the results with those in a previous report from 2020.

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RapidArc Dynamic (RAD) multi-mechanical axis optimization achieves enhanced OAR sparing in cervical cancer: A dosimetric comparison study. reports: To overcome limitations of conventional VMAT for cervical cancer, specifically restricted OAR sparing due to static collimators and delivery constraints inherent to dynamic modulation, we systematically evaluate RapidArc Dynamic (RAD) technology. This first comprehensive assessment focuses on RAD's multi-axis coordination for optimized pelvic radiotherapy planning. Twenty cervical cancer patients treated with TrueBeam whose energy was 6MV X-ray were retrospectively analyzed.

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Case Report: A rare case of external iliac artery rupture and sigmoid fistula following multimodal treatment for cervical cancer. reports: We report a 58-year-old woman with cervical squamous cell carcinoma who developed an early-onset left external iliac artery rupture followed by a sigmoid fistula after multimodal treatment. Notably, key baseline tumor parameters-including maximal tumor diameter and stromal invasion depth-were not documented preoperatively because PET-CT was not performed and the original MRI/CT datasets from the outside hospital were unavailable. This incomplete staging likely contributed to underestimation of disease extent and to selection of a non-guideline-concordant primary radical hysterectomy, although postoperative pathology ultimately confirmed FIGO 2018 stage IIIC2 disease with extensive nodal metastases.

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Knowledge, Attitude, and Practice among school students and teachers about the Human Papillomavirus vaccine in Central Kerala- a cross-sectional study reports: BackgroundHuman Papillomavirus (HPV) is the fourth most common cancer among women globally and a major public health concern. Uptake of HPV vaccine remains low despite its availability, in several countries, including India. India planned to introduce the HPV vaccine into the Universal Immunization Program (UIP), aiming to improve vaccine coverage. This is a preprint and not peer reviewed.

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Integrative Multi-omics of Gynecological Tumors Identifies Novel Singular Biomarkers of Disease Progression reports: Gynecological cancers represent a cluster of largely preventable and treatable diseases afflicting women, but with persistent substantial global burden of disease complicated by extant social factors especially in developing countries. Cervical, ovarian and endometrial cancers comprise the major gynecological cancers that might benefit from early-stage diagnosis and personalized treatment strategies. In this work, we performed integrative multi-omics analysis of public-domain omics datasets from The Cancer Genome Atlas consortium and coupled it with custom protocols to identify consensus candidate biomarkers of each of the major gynecological cancers. This is a preprint and not peer reviewed.

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ARVs is for HIV and cream is for HPV or precancer: Womens Perceptions and Perceived Acceptability of Self-Administered Topical Therapies for Cervical Precancer Treatment: A Qualitative Study from Kenya reports: BackgroundWomen in low- and middle-income countries (LMICs) bear a disproportionate burden of cervical cancer, despite being a preventable disease. Prevention efforts in LMICs are hindered in part by lack of access to cervical precancer treatment, due to weak health infrastructure and a lack of adequate human resources to deliver current provider-administered precancer treatments. Innovative strategies are urgently needed to close the cervical precancer treatment gap in LMICs, including the use of self-administered topical therapies such as 5-fluorouracil and imiquimod, for which efficacy evidence is available from high-income settings. This is a preprint and not peer reviewed.

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Phase I study on the pharmacokinetics of intravaginal, self-administered artesunate vaginal pessaries among women in Kenya. reports: Cervical cancer remains a significant global health issue, especially in low- and middle-income countries (LMICs), where access to prevention and treatment is limited and women are at a higher risk of cervical cancer. Artesunate, a widely available drug used to treat malaria, has shown promise in treating human papillomavirus (HPV)-associated anogenital lesions including high-grade cervical precancer, in a recent Phase I studies in the United States. Data on the pharmacokinetics of artesunate following intravaginal use, and its implications on malaria resistance, are lacking. This is a preprint and not peer reviewed.

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Photobiomodulation therapy approach to a rare phenomenon of radiation recall reaction triggered by cisplatin in a cervical cancer patient: a case report and scoping review. reports: Radiation recall reaction (RRR) is a rare and poorly understood phenomenon of tissue radiotoxicity. It is typically triggered by exposure to certain agents, most commonly cytotoxic drugs such as cisplatin. We conducted a scoping review following the methodology proposed by the JBI collaboration and PRISMA-ScR extension.

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Unlocking economic gains: the impact of image-guided brachytherapy on cervical cancer treatment in Thailand. reports: This study aims to bridge the existing gap in knowledge by assessing the financial impact of image-guided brachytherapy (IGBT) in the management of cervical cancer in Thailand. A web-based questionnaire was developed in 2019 to collect data from 14 radiotherapy centers across all regions of Thailand. The survey gathered information on the use of brachytherapy for cervical cancer treatment, encompassing both conventional brachytherapy (point-based prescription) and IGBT (volume-based prescription).

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