Topics
Biology / Mechanism, Outcomes / Survival, Prevention / Risk, Epidemiology
Modality
Targeted therapy, Imaging
Study type
Observational
Abstract
Background/ObjectivesGastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with significant racial and ethnic disparities in incidence, molecular characteristics, and patient outcomes. However, genomic studies focusing on Hispanic/Latino (H/L) populations remain scarce, limiting our understanding of ethnicity-specific molecular alterations. This study aims…
Authors
Monge, C., Waldrup, B., Carranza, F. G., Velazquez-Villarreal, E.
AI-generated summary
Molecular alterations in TP53, WNT, PI3K, TGF-Beta and RTK/RAS pathways in gastric cancer among ethnically heterogeneous cohorts reports: Background/ObjectivesGastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with significant racial and ethnic disparities in incidence, molecular characteristics, and patient outcomes. However, genomic studies focusing on Hispanic/Latino (H/L) populations remain scarce, limiting our understanding of ethnicity-specific molecular alterations. This study aims to characterize pathway-specific mutations in TP53, WNT, PI3K, TGF-Beta and RTK/RAS signaling pathways in GC and compare mutation frequencies between H/L and Non-Hispanic White (NHW) patients. This is a preprint and not peer reviewed.
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Primary source: medRxiv (not peer reviewed).